By altering genetic material in cells, gene therapies create permanent changes that can result in lifelong cures for diseases. As of August 2022, more than 2,000 gene therapies were in development, with approximately 1,000 active clinical trials globally. However, this rapid rise in gene therapy research is not evenly distributed around the world. Less than 5% of clinical trials were recruiting participants in LMICs (not including China), with only four trials in all of Africa.